학력

• 부산대학교 분자생물학과 이학사 (1996~2004)
• 아주대학교 의학과 약리학 전공 의학석사 (2004~2006)
• 서울대학교 의학과 약리학 전공 이학박사 (2006~2010)

주요경력

• 현) 을지대학교 화장품과학전공 부교수 (전공장)
• 현) 을지대학교 피부생명과학연구소 (Skin Bioscience R&D Center) 소장
• 현) 을지대학교 취창업지원센터장
• 현) 대한화장품학회 편집이사
• 현) 대한약리학회 산학협력이사
• 현) 대한미용학회 편집위원장
• 현) 코스인 프레그런스 저널 편집위원
• 전) 을지대학교 창업보육센터장
• 전) 한국인체미용예술학회 화장품분과 위원장
• 전) 이화여자대학교 (약학과), 건국대학교 (뷰티화장품학과) 외래강사
• 전) 2010년1월 ~ 2018년2월 : ㈜아모레퍼시픽 기술연구원 책임연구원

연구분야

• 화장품 효능소재 스크리닝 및 동물대체시험 효력평가법 개발
• 피부질환(탈모, 아토피피부염, 색소질환 등) 및 소재 약리 기전 연구
• 화장품 기업 연구소 효능평가 및 소재개발 자문
• R&D 산학협력 : ㈜아모레퍼시픽, ㈜신세계인터내셔날, ㈜엑티브온, ㈜두래, ㈜오가노이드사이언스, ㈜웰메이드생활건강, ㈜한국의생명연구원 등

연구실적 [논문 (SCIE 주저자 기준)]

• 2,4,6-Triphenyl-1-hexene, an Anti-Melanogenic Compound from Marine-Derived Bacillus sp. APmarine135. Mar Drugs. 2024,22, 72.
• The protective effect of alfalfa (Medicago sativa L.) seed extract containing polysaccharides on human keratinocytes and fibroblasts. Arch Biol Sci. 2023;75(3);279-286.
• Retinoic acid induces hyaluronic acid production through the klotho-mediated EGFR signaling pathway in human epidermal keratinocytes. Arch Biol Sci. 2022;74(1);91-96
• SNA077, an Extract of Marine Streptomyces sp., Inhibits Melanogenesis by Downregulating Melanogenic Proteins via Inactivation of cAMP/PKA/CREB Signaling. Int J Mol Sci. 2022;23;23.
• Pseudoalteromone A, a Ubiquinone Derivative from MarinePseudoalteromonas spp., Suppresses Melanogenesis. Mar Drugs. 2021;19(11);612
• Potential therapeutic properties of Sorbus commixta twig ethanol extract on vitiligo inskin cells. Arch Biol Sci. 2021;73(4);483-490
• All-trans retinoic acid prevents oxidative stress-mediated cellular senescence viaupregulation of insulin-like growth factor binding protein-6 in normal human epidermalkeratinocytes. Arch Biol Sci. 2021;73(3);425-432
• The Protective Effect of Ganoderma lucidum Extract in Ultraviolet B-Induced Human Dermal Fibroblasts and Skin Equivalent Models. Ann Dermatol. 2020;32(3);251-254.
• Synthetic Retinoid Seletinoid G Improves Skin Barrier Function through Wound Healing and Collagen Realignment in Human Skin Equivalent Models. Int J Mol Sci. 2020;30;21(9):3198.
• Glucose Exerts an Anti-Melanogenic Effect by Indirect Inactivation of Tyrosinase in Melanocytes and a Human Skin Equivalent. Int J Mol Sci. 2020;3;21(5):1736.
• Rhododenol Activates Melanocytes and Induces Morphological Alteration at Sub-Cytotoxic Levels. Int J Mol Sci. 2019;12;20(22):5665.
• Anti-inflammatory effect of green tea petiole extracts in poly(I:C)-stimulated human epidermal keratinocytes and a human 3D skin equivalent. Eur J Inflamm. 2019;17;1-6.
• Mannosylerythritol lipids inhibit melanogenesis via suppressing ERK-CREB-MiTF-tyrosinase signalling in normal human melanocytes and human skin equivalent. Exp Dermatol. 2019;28(6):738-741.
• Whitening efficacy of ginsenoside F1 through inhibition of melanin transfer in cocultured human melanocytes-keratinocytes and three-dimensional (3-D) human skin equivalent. J Ginseng Res. 2019;43(2):300-304.
• Protopanaxatriol inhibits melanin synthesis through inactivation of the pCREB-MITF-tyrosinase signalling pathway in melanocytes. Clin Exp Dermatol. 2019;44(3):295-299.
• Mannosylerythritol lipids ameliorate ultraviolet A-induced aquaporin-3 downregulation by suppressing c-Jun N-terminal kinase phosphorylation. Korean J Physiol Pharmacol. 2019;23(2):113-120.
• Reduced humidity induces skin barrier dysfunction and secretion of dipeptidyl peptidase-4 (DPP-4) in a skin-equivalent model. Arch Biol Sci. 2019;71(4);697-702
• Camellia sinensis leaf extracts lacking catechins exert depigmentary effects through ERK-dependent, MiTF-mediated tyrosinase downregulation. Arch Biol Sci. 2019;71(3);483-488
• Ameliorating effect of dipotassium glycyrrhizinate on an IL-4-and IL-13-induced atopic dermatitis-like skin-equivalent model. Arch Dermatol Res. 2019;311(2):131-140.
• Depigmentation efficacy of galacturonic acid through tyrosinase regulation in B16 murine melanoma cells and a three-dimensional human skin equivalent. Baek HS, Bae IH, Choi SJ, Kim YJ, Lee JH, Kim JW, Lee CS. Clin Exp Dermatol. 2018;43(6):708-712
• Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment. Park M, Naidoo AA, Burns A, Choi JK, Gatfield KM, Vidgeon-Hart M, Bae IH, Lee CS, Choi G, Powell AJ, Park YH, Fagg R. Cell Biol Toxicol. 2018;34(2):143-162.
• Antimelanogenic Efficacy of Melasolv (3,4,5-Trimethoxycinnamate Thymol Ester) in Melanocytes and Three-Dimensional Human Skin Equivalent. Lee JH, Lee ES, Bae IH, Hwang JA, Kim SH, Kim DY, Park NH, Rho HS, Kim YJ, Oh SG, Lee CS. Skin - Pharmacol Physiol. 2017;30(4):190-196
• Antimelanogenic Efficacy of Melasolv (3,4,5-Trimethoxycinnamate Thymol Ester) in Melanocytes and Three-Dimensional Human Skin Equivalent. Lee JH, Lee ES, Bae IH, Hwang JA, Kim SH, Kim DY, Park NH, Rho HS, Kim YJ, Oh SG, Lee CS. Skin Pharmacol Physiol. 2017;30(4):190-196
• AP736 induces miR-125b expression for the efficient whitening and anti-ageing action in human epidermal cells. Baek HS, Hwang JA, Bae IH, Kim KH, Joo YH, Kim YJ, Shin HJ, Lee JH, Park YH, Kim JW, Lee CS. Exp Dermatol. 2017 May;26(5):451-454.
• Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase. Hwang JA, Park NH, Na YJ, Lee HK, Lee JH, Kim YJ, Lee CS. Biol Pharm Bull. 2017;40(4):535-539.
• Antimelanogenic activity of a novel adamantyl benzylbenzamide derivative, AP736: a randomized, double-blind, vehicle-controlled comparative clinical trial performed in patients with hyperpigmentation during the summer. Jeong YS, Kim JH, Choi J, Baek HS, Joo YH, Lee CS, Shin HJ, Park YH, Kim BJ, Shin SS. Int J Dermatol. 2016 Jun;55(6):e321-6.
• Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response. Kim HS, Kim BH, Jung JE, Lee CS, Lee HG, Lee JW, Lee KH, You HJ, Chung MH, Ye SK. Free Radic Biol Med. 2016 Apr;93:12-22.
• Different effects of five depigmentary compounds, rhododendrol, raspberry ketone, monobenzone, rucinol and AP736 on melanogenesis and viability of human epidermal melanocytes. Lee CS, Joo YH, Baek HS, Park M, Kim JH, Shin HJ, Park NH, Lee JH, Park YH, Shin SS, Lee HK. Exp Dermatol. 2016 Jan;25(1):44-9
• A novel adamantyl benzylbenzamide derivative, AP736, inhibits melanogenesis in B16F10 mouse melanoma cells via glycogen synthase kinase 3β phosphorylation. Shin HJ, Oh CT, Kwon TR, Beak HS, Joo YH, Kim JH, Lee CS, Lee JH, Kim BJ, Shin SS, Park ES. Int J Mol Med. 2015 Nov;36(5):1353-60.
• Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs. Jeong HJ, Lee CS, Choi J, Hong YD, Shin SS, Park JS, Lee JH, Lee S, Yoon KD, Ko J. Bioorg Med Chem Lett. 2015 Feb 15;25(4):799-802.
• Compound K inhibits MMP-1 expression through suppression of c-Src-dependent ERK activation in TNF-α-stimulated dermal fibroblast. Lee CS, Bae IH, Han J, Choi GY, Hwang KH, Kim DH, Yeom MH, Park YH, Park M. Exp Dermatol. 2014 Nov;23(11):819-24
• NF-κB/AP-1-targeted inhibition of macrophage-mediated inflammatory responses by depigmenting compound AP736 derived from natural 1,3-diphenylpropane skeleton. Ha VT, Beak HS, Kim E, Baek KS, Hossen MJ, Yang WS, Kim Y, Kim JH, Yang S, Kim JH, Joo YH, Lee CS, Choi J, Shin HJ, Hong S, Shin SS, Cho JY. Mediators Inflamm. 2014;2014:354843.
• A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression. Lee CS, Jang WH, Park M, Jung K, Baek HS, Joo YH, Park YH, Lim KM. Exp Dermatol. 2013 Nov;22(11):762-4
• Sophoraflavanone G induces apoptosis of human cancer cells by targeting upstream signals of STATs. Kim BH, Won C, Lee YH, Choi JS, Noh KH, Han S, Lee H, Lee CS, Lee DS, Ye SK, Kim MH. Biochem Pharmacol. 2013 Oct 1;86(7):950-9.
• Simvastatin suppresses RANTES-mediated neutrophilia in polyinosinic-polycytidylic acid-induced pneumonia. Lee CS, Yi EH, Lee JK, Won C, Lee YJ, Shin MK, Yang YM, Chung MH, Lee JW, Sung SH, Ye SK. Eur Respir J. 2013 May;41(5):1147-56.
• Carnosic acid, a phenolic diterpene from rosemary, prevents UV-induced expression of matrix metalloproteinases in human skin fibroblasts and keratinocytes. Park M, Han J, Lee CS, Soo BH, Lim KM, Ha H. Exp Dermatol. 2013 May;22(5):336-41
• Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation. Lee CS, Park M, Han J, Lee JH, Bae IH, Choi H, Son ED, Park YH, Lim KM. J Invest Dermatol. 2013 Apr;133(4):1063-71.
• STAT3-RANTES autocrine signaling is essential for tamoxifen resistance in human breast cancer cells. Yi EH, Lee CS, Lee JK, Lee YJ, Shin MK, Cho CH, Kang KW, Lee JW, Han W, Noh DY, Kim YN, Cho IH, Ye SK. Mol Cancer Res. 2013 Jan;11(1):31-42
• Adamantyl N-benzylbenzamide: new series of depigmentation agents with tyrosinase inhibitory activity. Baek HS, Hong YD, Lee CS, Rho HS, Shin SS, Park YH, Joo YH. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2110-3
• Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis. Lee MJ, Lee JK, Choi JW, Lee CS, Sim JH, Cho CH, Lee KH, Cho IH, Chung MH, Kim HR, Ye SK. PLoS One. 2012;7(9):e38801.
• Anti-dermatitis effects of oak wood vinegar on the DNCB-induced contact hypersensitivity via STAT3 suppression. Lee CS, Yi EH, Kim HR, Huh SR, Sung SH, Chung MH, Ye SK. J Ethnopharmacol. 2011 Jun 1;135(3):747-53.
• CADPE suppresses cyclin D1 expression in hepatocellular carcinoma by blocking IL-6-induced STAT3 activation. Won C, Lee CS, Lee JK, Kim TJ, Lee KH, Yang YM, Kim YN, Ye SK, Chung MH. Anticancer Res. 2010 Feb;30(2):481-8.
• Zeolite 4A, a synthetic silicate, suppresses melanogenesis through the degradation of microphthalmia-associated transcription factor by extracellular signal-regulated kinase activation in B16F10 melanoma cells. Shin YJ, Han CS, Lee CS, Kim HS, Ko SH, Hwang SK, Ko SG, Shin JW, Ye SK, Chung MH. Biol Pharm Bull. 2010;33(1):72-6.
• Inhibition of double-stranded RNA-induced inducible nitric oxide synthase expression by fraxinellone and sauchinone in murine microglia. Lee CS, Won C, Yoo H, Yi EH, Cho Y, Maeng JW, Sung SH, Ye SK, Chung MH. Biol Pharm Bull. 2009 Nov;32(11):1870-4.
• Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes. Lee JH, Park SM, Kim OS, Lee CS, Woo JH, Park SJ, Joe EH, Jou I. Mol Cell. 2009 Sep 24;35(6):806-17.
• Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. Lee CS, Shin YJ, Won C, Lee YS, Park CG, Ye SK, Chung MH. Biocell. 2009 Aug;33(2):107-14.
• LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression. Kim JE, Kim HS, Shin YJ, Lee CS, Won C, Lee SA, Lee JW, Kim Y, Kang JS, Ye SK, Chung MH. Exp Mol Med. 2008 Oct 31;40(5):514-22.
• STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination. Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH. Exp Mol Med. 2008 Oct 31;40(5):479-85.
• Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells. Jung JE, Kim HS, Lee CS, Park DH, Kim YN, Lee MJ, Lee JW, Park JW, Kim MS, Ye SK, Chung MH. Carcinogenesis. 2007 Aug;28(8):1780-7.
• Oxidized low density lipoprotein suppresses lipopolysaccharide-induced inflammatory responses in microglia: oxidative stress acts through control of inflammation. Kim OS, Lee CS, Joe EH, Jou I. Biochem Biophys Res Commun. 2006 Mar 31;342(1):9-18.
• Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. Lee CS, Joe EH, Jou I. Neuroreport. 2006 Feb 6;17(2):183-7.
• Characterization of new microglia-like cells obtained from neonatal rat brain. Kim OS, Lee CS, Kim HY, Joe EH, Jou I. Biochem Biophys Res Commun. 2005 Mar 4;328(1):281-7.

연구실적[특허]

• 등록번호 10-1604053 신규 벤조산아미드 화합물
• 등록번호 10-1338681 밤껍질 추출물을 포함하는 건강 식품 또는 약학 조성물
• 출원번호 10-2015-0045201 신규 벤조산 아마이드 화합물
• 출원번호 10-2015-0028474 미백성분의 부작용을 예측하는 방법
• 출원번호 10-2013-0032634 신규 페닐초산 아미드 유도체 화합물
• 출원번호 10-2012-0078675 간 X 수용체 활성제를 포함하는 피부 미백제
• 출원번호 10-2011-0065010 신규한 코지산 유도체, 이의 제조 방법 및 이를 유효성분으로 함유하는 피부 미백용 조성물
• 출원번호 10-2011-0064294 물푸레나무 추출물의 발효물을 포함하는 피부 미백용 조성물